Bronson Price: 1905-1978

Bronson Price: 1905-1978. In memoriam.

It is likely that the best-known paper on twins, at least in the English language, is " Primary biases in twin studies ". Although published as a review, it was more nearly a monograph and presented the most thorough discussion, then or now, of the potential effects of intrauterine phenomena on twin differences after birth. The paper called attention to peculiarities of development in twins: la...

Henry Bronson, M.D

Every student of local medical history realizes the great obligation he owes Doctor Henry Bronson. Our knowledge of the lives of our illustrious forebears and of local history in general would be limited and miscellaneous indeed had it not been for his painstaking research and scholarly writing which provided a record presented in orderly and artistic fashion. It is never possible to tell just ...

Dmd059121 1890..1905

Subcutaneous injection is an important route of administration for therapeutic proteins that provides several advantages over other modes of parenteral delivery. Despite extensive clinical use, the exact mechanism underlying subcutaneous absorption of proteins is not completely understood, and the accuracy of prediction of absorption of biotherapeutics in humans remains unsatisfactory. This rev...

Dmd065763 1905..1916

Montelukast has been recommended as a selective in vitro and in vivo probe of cytochrome P450 (P450) CYP2C8 activity, but its selectivity toward this enzyme remains unclear. We performed detailed characterization of montelukast metabolism in vitro using human liver microsomes (HLMs), expressed P450s, and uridine 59-diphospho-glucuronosyltransferases (UGTs). Kinetic and inhibition experiments pe...

Phoebus A. Levene, 1905